Maternal and Sex‐Specific Fetal Characteristics of Three Different Mouse Models for Fetal Programming by Preeclampsia
نویسندگان
چکیده
منابع مشابه
Maternal-fetal interactions, predictive markers for preeclampsia, and programming.
During pregnancy close interactions between the maternal system and the fetal system via the placenta exist that result in a powerful crosstalk between both individuals. Looking for predictive biomarkers in maternal blood is extremely difficult because of this crosstalk as such markers may be derived from only maternal sources, only placental sources or both. In particular, the concentrations o...
متن کاملMaternal and Fetal Consequences of Preeclampsia
About 6 to 8 percent of all pregnancies, especially primigravidae is complicated by preeclampsia, a classical triad of elevated blood pressure, proteinuria and edema. Maternal and neonatal morbidity and mortality are of utmost concern as the etiology of preeclampsia is uncertain. At-risk pregnant women can be suspected if they are primigravidae, multiparous, obesed, diabetic, hypertensive, or i...
متن کاملMaternal Nutrition and Fetal Programming
Introduction The maternal system can be influenced by many different extrinsic factors, including nutritional status, which can program nutrient partitioning and ultimately growth, development and function of the major fetal organ systems (Wallace, 1948; Wallace et al., 1999; Godfrey and Barker, 2000; Wu et al., 2006). The trajectory of prenatal growth is sensitive to direct and indirect effect...
متن کاملMaternal-fetal metabolism in normal pregnancy and preeclampsia.
Adaptation to pregnancy in humans involves major anatomic, physiologic and metabolic changes in the mother in order to support and provide for the nutritional and metabolic needs of the growing conceptus. Metabolically, pregnancy is marked by several important and dynamic adjustments including increased insulin resistance, hyperlipidemia and changes in protein and amino acid metabolism. In gene...
متن کاملQuantitative abnormalities of fetal DNA in maternal serum in preeclampsia.
BACKGROUND There is much recent interest in the biologic and diagnostic implication of cell-free non-host DNA in the plasma and serum of human subjects. To determine if quantitative abnormalities of circulating non-host DNA may be associated with certain pathologic processes, we used circulating fetal DNA in preeclampsia as a model system. METHODS We studied 20 preeclamptic women and 20 contr...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2019
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2019.33.1_supplement.758.2